Introduction 


1.    Till very recently, studies by renowned medical experts and dieticians have proven that the use of low-carb and High Fat (LCHF) diets could effectively be used to treat Kidney disorders, Diabetes type 2, Weight Management, and many other health issues except heart. This could save the patients from adverse side effects of medications as well as financial burdens. However, there was no study conducted to prove that failing heart symptoms can be treated with a diet. The fear surrounding the adoption of a high-fat diet for heart health has been debunked by the realization that the heart relies on such a diet for optimal functioning. The publication of detailed findings now substantiates the perspective held by dieticians – that addressing failed or failing hearts is plausible through a diet characterized by low carbohydrates and high fats (protein), commonly known as the Ketogenic diet. This marks a significant shift in understanding, dispelling misconceptions, and opening avenues for embracing dietary approaches that align with the heart's metabolic requirements. 


The Study 


2.    The journal Science released an article titled "Comprehensive quantification of fuel use by the failing and nonfailing human heart" on October 16, 2020, by a group of authors including Danielle Murashige. The goal of the study was to give a thorough understanding of how the human heart uses fuel and goes through its metabolic processes, especially when heart failure is present. 


3.    Abstract of the Study. The heart is an essential organ that contracts throughout life. To produce adenosine triphosphate (ATP) for energy through oxidative phosphorylation, the heart needs a constant flow of oxygen and nutrients. One common metaphor for heart failure, a major cause of death worldwide, is an "engine out of fuel," unable to effectively employ circulating nutrients to fulfill its needs for metabolism. The goal of this work was to map out in detail how the human heart uses fuel in both failing and nonfailing situations. 


4.    Methods Used. Using metabolomics, the researchers examined blood samples from 110 patients—110 with and 110 without heart failure—from the radial artery, coronary sinus, and femoral vein. To provide a complete picture of how human cardiac fuel is used, they measured the intake and release of 277 metabolites, including key nutrients. 


Principal Results  

5.    Remarkably little glucose and mostly fatty acids were used by the human heart. The active secretion of glutamine and other nitrogen-rich amino acids suggests that the heart undergoes a substantial amount of protein breakdown—10 times as much as the leg. Ketones, glutamate, and acetate were consumed by the leg and the heart in exact proportion to the quantities that were in circulation. The failing heart showed higher rates of proteolysis (breakdown of proteins) and increased consumption of lactate and ketones. 

6.    Fuel of the Heart (Normal and Failed Heart)     

Serial 

Details 

Quantity Consumed  

 

Change from Normal heart values

Normal Heart 

Failing Heart 

1. 

Fatty Acids 

85.5% 

71.4% 

Decrease 14.1% 

2. 

Amino Acids (Protein) 

4.6 % 

6.7% 

Increase 2.1% 

3. 

Ketone 

6.4% 

16.4% 

Increase 10% 

4. 

Lactate 

2.8 % 

5.0% 

Increase 2.2% 

5. 

Glucose 

<1% 

<1% 

No change 

 

7.    The results of the study showed that the heart's net negative nitrogen balance indicated active proteolysis and the release of amino acids. The heart and leg released TCA cycle intermediates even though they relied on the TCA (tricarboxylic acid) cycle to produce ATP (adenosine triphosphate), to avoid overstimulation of metabolic pathways. The research shed light on the relative contributions of different substrates to the synthesis of cardiac ATP under situations with preserved and lowered ejection fraction. 


8.    The study provides a thorough and quantitative understanding of how human cardiac fuel is used, illuminating the differences in the metabolic profiles of the leg and heart. The primary cardiac fuel source was found to be fatty acids, and surprising findings, Active proteolysis, and restricted glucose uptake, for example, strengthen our knowledge of cardiac metabolism in both health and disease, especially heart failure. This work lays the groundwork for future research to create focused treatments for heart failure and offers insightful information on the complex metabolic workings of the human heart. 


Case Studies 


9.    There have been two instances narrated by a renowned nutritionist, where patients having heart failure used a Keto Diet for weight loss and not only lost weight but also astonishingly raised their Heart Ejection Fraction between 25 – 40 %. 


10.    The Founder and Director of Content Managers underwent a series of heart attacks, beginning in 2009 when five stents were placed. He was advised to take a handful of medicines, and due to their side effects, he developed Type 2 diabetes, fatty liver, kidney disorder, and other minor health issues. In 2014, he experienced a second heart attack, revealing a 100% blockage in the RCA (Right Coronary Artery) that could not be addressed during angiography. Medications were intensified, leading to a further decline in his health. The situation worsened with a severe third heart attack in December 2016, involving 100% blockage in the RCA, 70% in the Cx, and 90% in the LAD (Left Anterior Descending). A heart bypass was recommended. In an alternative approach, he turned to dried pomegranate seeds (Anardana) for approximately 9 weeks (about 2 months), successfully opening all three arteries. Continued use over the next 8 months, with intervals, helped him overcome diabetes, fatty liver, kidney disorder, and other minor health problems. Embracing a Ketogenic Diet for three months in 2022 solidified his belief in its efficacy. Today, he at 68, is in good health, sharing his experiences on YouTube at 'Youtube.com/shazain88' and contributing articles to 'healthierhtips.blogspot.com.' 


Keto Diet and Fueling Heart Muscles 


11.    The findings of the study on comprehensive quantification of fuel use by the human heart provide insights into the metabolic processes of the heart and have implications for dietary choices, including the ketogenic (keto) diet. While it is important to note that the study primarily focused on understanding cardiac metabolism under different conditions, here are some considerations when relating these findings to the implementation of a keto diet for overall health: 


12.    Fatty Acid Utilization. The study revealed that the human heart primarily consumes fatty acids for energy. This aligns with the central principle of a ketogenic diet, which encourages the body to rely on fat for fuel by reducing carbohydrate intake. In a state of ketosis, the body produces ketones from fat, which can serve as an alternative energy source for various organs, including the heart. 


13.    Limited Glucose Uptake. The study showed limited glucose uptake by the heart, particularly in the fasting state. In a ketogenic diet, carbohydrate intake is restricted, leading to reduced reliance on glucose. Instead, the body shifts to utilizing ketones and fatty acids for energy. This is consistent with the idea of a keto diet, which aims to promote fat metabolism over glucose metabolism. 


14.    Amino Acid Release and Protein Breakdown. The study discovered that the heart actively breaks down proteins and releases amino acids. The keto diet emphasizes moderate protein intake, even if it's not always a high-protein diet. To meet the body's needs, maintain muscle mass, and stop excessive protein breakdown, it is imperative to make sure you are getting enough protein in your diet.  

 

15.    Ketone Consumption and Heart Health. The research indicated that both the heart and leg consumed ketones, and the failing heart showed increased ketone consumption. Some studies suggest the potential benefits of ketones for heart health, and a ketogenic diet may influence factors such as inflammation and oxidative stress.  


16.    General Fitness and Health.  Although the heart was the focus of the study, the ketogenic diet has also been investigated for benefits in controlling blood sugar, managing weight, and treating neurological disorders. However, not everyone should follow a diet, so it is important to consider your health objectives and circumstances. 


Conclusion 


17.    As we navigate through evolving perspectives on heart health, it becomes evident that personalized approaches, such as incorporating Keto diets, can play a pivotal role in not only managing but also improving cardiac well-being. The narratives shared by individuals who have experienced positive outcomes serve as beacons of hope and encouragement, inspiring further exploration into the intersection of nutrition, metabolism, and cardiovascular health.  

18. By accepting these discoveries, we open a new chapter in knowledge where customized dietary therapies could be useful allies in the quest for a robust and healthy heart. It is a paradigm change that promotes continued study, candid communication, and information sharing to enable people to make educated decisions for a heart-healthy lifestyle. Before starting any diet program, including the ketogenic diet, individuals should consult with healthcare professionals, especially if they have pre-existing health conditions. 


Disclaimer 


This article/blog contains information that is just meant to be informative and educational. Advice, diagnosis, or treatment related to medicine are not meant by this. For information about any medical issue or concern, always consult a licensed healthcare provider. It is your responsibility to use the information in this blog or article. If any liability, loss, or risk—personal or otherwise—occurs from using the information supplied, it is not the responsibility of the author(s) or publisher(s). Before making any big adjustments to your diet, exercise routine, or medical regimen, get advice from a healthcare provider.